Type 2 diabetes (T2D) shows a high comorbidity with depression and there is strong evidence for a bi-directional relationship. However, the role of clinically relevant depression for diabetes prevention is still unclear. In a recent study, we investigated the prospective impact of major depressive disorder (MDD) on glycaemic changes after 12 years.
The study was based on a cohort of adults aged 18-65 years without diabetes who participated in the mental health supplement of the German National Health Interview and Examination Survey (GNHIES98-MHS, 1997–1999, baseline) and in a follow-up survey (DEGS1, 2008–2011). Set against further known type 2 diabetes risks as well as antidepressant and mental health care use, major depressive disorder at baseline had a sex-specific impact on changes in glycaemic status after 12 years: Among women, MDD was associated with a lower chance for remission from prediabetes to normoglycemia. Among men, MDD was not significantly related to glycaemic changes over time. Furthermore, MDD had no significant effect on incident T2D. In conclusion, our findings highlight the role of MDD in the prevention of T2D – particularly among women.
The full article entitled Sex-specific impact of major depressive disorder on 12-year change in glycaemic status: Results from a nationwide cohort study of adults without diabetes in Germany can be found here.
Interactive visualizations in regard with depressive symptoms among persons with and without diabetes can be found here.